CPRiL

Hspa5

heat shock protein family A (Hsp70) member 5

Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and luteolysis. Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including dendritic shaft; neuronal cell body; and smooth endoplasmic reticulum. Biomarker of metabolic dysfunction-associated steatohepatitis; post-traumatic stress disorder; steatotic liver disease; transient cerebral ischemia; and ureteral obstruction. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Jul 2025]

• endoplasmic reticulum chaperone BiP
• 78 kDa glucose-regulated protein
• GRP-78
HSP70 family protein 5
binding-immunoglobulin protein
heat shock 70 kDa protein 5
heat shock 70kD protein 5
heat shock 70kDa protein 5 (glucose-regulated protein)
heat shock protein 5
heat shock protein 70 family protein 5
heat shock protein family A member 5
immunoglobulin heavy chain-binding protein
steroidogenesis-activator polypeptide
BIP
GRP 78
GRP78