Title : Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter.

Pub. Date : 1998 Dec 25

PMID : 9857074






5 Functional Relationships(s)
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Protein Name
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1 Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. ikaros granzyme B Homo sapiens
2 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros granzyme B Homo sapiens
3 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros granzyme B Homo sapiens
4 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros granzyme B Homo sapiens
5 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros granzyme B Homo sapiens