Pub. Date : 1998 Dec
PMID : 9844922
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Taxol-induced G2/M transition is mediated by p34(cdc-2) (CDK1) which, if prematurely activated, may also trigger apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Taxol-induced G2/M transition is mediated by p34(cdc-2) (CDK1) which, if prematurely activated, may also trigger apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Data presented here show that, while Taxol-induced peak CDK1 kinase activity occurs earlier in HL-60/neo cells, there are no significant differences in cyclin B1 accumulation, tyrosine dephosphorylation of CDK1, and mitotic arrest of Taxol-treated HL-60/neo vs HL-60/Bcl-xL cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Taxol-induced CDK1 activation and mitosis preceded the cytosolic accumulation (approximately six-fold) of cyt c. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |