Pub. Date : 1998 Nov
PMID : 9844631
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Taxol activates p34Cdc2 kinase in MDA-MB-435 breast cancer cells, leading to cell cycle arrest at the G2/M phase and, subsequently, apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | A chemical inhibitor of p34Cdc2 and a dominant-negative mutant of p34Cdc2 blocked Taxol-induced apoptosis in these cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | A chemical inhibitor of p34Cdc2 and a dominant-negative mutant of p34Cdc2 blocked Taxol-induced apoptosis in these cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol-mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |