Pub. Date : 1998 Dec
PMID : 9843865
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 2 | Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 3 | These findings suggest that the central IL-1beta-induced fever in rats is mediated, at least partly, by activation of EP1 receptors by PGE2. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |