PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9843865-1 1998 We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Dinoprostone 54-58 prostaglandin E receptor 1 Rattus norvegicus 103-106 9843865-2 1998 Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. Dinoprostone 43-47 prostaglandin E receptor 1 Rattus norvegicus 160-163 9843865-6 1998 These findings suggest that the central IL-1beta-induced fever in rats is mediated, at least partly, by activation of EP1 receptors by PGE2. Dinoprostone 135-139 prostaglandin E receptor 1 Rattus norvegicus 118-121