Title : Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).

Pub. Date : 1998 Nov 10

PMID : 9843384






1 Functional Relationships(s)
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1 Both the R state of the receptor and the Tyr4 Ang II dependence of receptor activation can be reinstated by introduction of a larger sized Phe side chain at the 111 position in CR18, suggesting that the CR18 mutation generated an effect similar to the reduction of side chain size in the N111G mutation. Phenylalanine angiotensinogen Homo sapiens