Title : Myocardial dysfunction in the septic rat heart: role of nitric oxide.

Pub. Date : 1998 Nov

PMID : 9840654






2 Functional Relationships(s)
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1 Perfusion of hearts in vitro with the iNOS inhibitor S-methylisothiourea did not reverse the sepsis-induced contractile dysfunction. S-methylisothiopseudouronium nitric oxide synthase 2 Rattus norvegicus
2 However, treatment of animals with S-methylisothiourea or dexamethasone, a glucocorticoid that prevents the synthesis of the iNOS, at the time of induction of sepsis resulted in partial but not complete attenuation of myocardial contractile dysfunction induced by sepsis. S-methylisothiopseudouronium nitric oxide synthase 2 Rattus norvegicus