Title : Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

Pub. Date : 1998 Dec 11

PMID : 9837978

1 Functional Relationships(s)
Compound Name
Protein Name
1 Both the c-Src and c-Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin, paxillin, IRS-1, the p85 subunit of phosphatidylinositol 3-kinase, C3G, SHC, Grb-2, and Sos-1. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus