Title : Interactions between the renin-angiotensin system (RAS) and the sympathetic system.

Pub. Date : 1998

PMID : 9833158






4 Functional Relationships(s)
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1 Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
2 Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
3 It has been demonstrated that ACE inhibition did not influence the net catecholamine overflow during stimulation of the sympathetic nerves in contrast to AT1 antagonists which can specifically and dose dependently diminish noradrenaline and adrenaline release, an effect that could be explained by a compensating mechanism of bradykinin. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
4 As could be demonstrated with losartan and HR 720, candesartan lowered AT1 receptor mediated angiotensin II-induced noradrenaline release in a dose-dependent manner. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus