Pub. Date : 1997 Jun
PMID : 9833017
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To determine the impact of impaired AMP metabolism on its behavioural effects, AMP-induced hyperactivity, AMP discrimination and AMP self-administration were examined in male Wistar rats with or without pretreatment with the CYP2D1 inhibitors quinine and budipine. | Quinine | cytochrome P450, family 2, subfamily d, polypeptide 1 | Rattus norvegicus |
| 2 | In vivo, quinine (20 mg/kg) and budipine (10 mg/kg) increased the plasma area under the curve of AMP 4-fold and 3.6-fold respectively, and decreased the plasma levels of 4-OH-AMP, 3-fold and 8.6-fold, confirming that the doses used suppressed CYP2D1 activity. | Quinine | cytochrome P450, family 2, subfamily d, polypeptide 1 | Rattus norvegicus |