PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9833017-2 1997 To determine the impact of impaired AMP metabolism on its behavioural effects, AMP-induced hyperactivity, AMP discrimination and AMP self-administration were examined in male Wistar rats with or without pretreatment with the CYP2D1 inhibitors quinine and budipine. Quinine 243-250 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 225-231 9833017-3 1997 In vivo, quinine (20 mg/kg) and budipine (10 mg/kg) increased the plasma area under the curve of AMP 4-fold and 3.6-fold respectively, and decreased the plasma levels of 4-OH-AMP, 3-fold and 8.6-fold, confirming that the doses used suppressed CYP2D1 activity. Quinine 9-16 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 243-249