Title : Molecular mechanisms regulating NGF-mediated enhancement of cholinergic neuronal phenotype: c-fos trans-activation of the choline acetyltransferase gene.

Pub. Date : 1998 Aug

PMID : 9826788






1 Functional Relationships(s)
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1 In the present study, treatment of cultured rat embryonic basal forebrain neurons with anti-c-fos, prior to administering NGF, blocked NGF-mediated increases in ChAT activity by 67%; basal ChAT activity was not affected by the antisense oligonucleotide treatment. Oligonucleotides Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus