Title : Development of tolerance to the antinociceptive effect of systemic morphine at the lumbar spinal cord level: a c-Fos study in the rat.

Pub. Date : 1998 Nov 30

PMID : 9824685






2 Functional Relationships(s)
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1 The development of tolerance to the antinociceptive effects of morphine was investigated in rats using carrageenin-induced spinal c-Fos expression. Carrageenan Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Two hours after intraplantar injection of carrageenin (6 mg/150 microliter of saline), c-Fos-like immunoreactivity (FLI) was observed predominantly in the superficial and deep laminae of the dorsal horn in segments L4 and L5 of the spinal cord. Carrageenan Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus