Title : Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells.

Pub. Date : 1998 Sep

PMID : 9818030






4 Functional Relationships(s)
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1 We found that treatment of cells with vinblastine induced phosphorylation of Bcl-2, resulting in the dissociation of Bcl-2 and Bax. Vinblastine BCL2 apoptosis regulator Homo sapiens
2 We found that treatment of cells with vinblastine induced phosphorylation of Bcl-2, resulting in the dissociation of Bcl-2 and Bax. Vinblastine BCL2 apoptosis regulator Homo sapiens
3 Thus, vinblastine-induced apoptosis might be mediated by the phosphorylation of Bcl-2, resulting in Bcl-2 inactivation, and by subsequent activation of caspase-3. Vinblastine BCL2 apoptosis regulator Homo sapiens
4 Thus, vinblastine-induced apoptosis might be mediated by the phosphorylation of Bcl-2, resulting in Bcl-2 inactivation, and by subsequent activation of caspase-3. Vinblastine BCL2 apoptosis regulator Homo sapiens