Title : Mutant K-ras oncogenes in colon cancers Do not predict Patient's chemotherapy response or survival

Pub. Date : 1995 Apr

PMID : 9816002






2 Functional Relationships(s)
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1 We studied 37 patients who received chemotherapy with 5-fluorouracil and leucovorin, Exon 1 of the c-K-ras gene was PCR amplified from DNA extracted from paraffin-embedded tumor blocks. Fluorouracil KRAS proto-oncogene, GTPase Homo sapiens
2 Patients with colon cancers bearing either wild-type or mutant c-K-ras alleles are indistinguishable in overall survival and are equally likely to respond to 5-fluorouracil-based chemotherapy. Fluorouracil KRAS proto-oncogene, GTPase Homo sapiens