Pub. Date : 1997 Jun
PMID : 9815762
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of RAR-beta mRNA was detected in 40% of the patients at baseline and increased to 90% of the patients after isotretinoin therapy (P < 0. | Isotretinoin | retinoic acid receptor beta | Homo sapiens |
| 2 | Eighty-three percent of patients having low p53 expression had up-regulation of RAR-beta mRNA after isotretinoin therapy, compared with 22% of patients with high p53 expression (P = 0.003). | Isotretinoin | retinoic acid receptor beta | Homo sapiens |
| 3 | The patients with low p53 protein expression at baseline and up-regulation of RAR-beta after isotretinoin therapy achieved a 70% rate of major response. | Isotretinoin | retinoic acid receptor beta | Homo sapiens |
| 4 | The patients with high p53 protein expression and either no change or down-regulation of RAR-beta had a response rate of only 14% to isotretinoin therapy. | Isotretinoin | retinoic acid receptor beta | Homo sapiens |