Title : A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling.

Pub. Date : 1998 Nov 16

PMID : 9815269






3 Functional Relationships(s)
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1 A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
2 A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
3 Taken together, these studies demonstrate that the COOH-terminal alpha-helical region of RANTES plays a key role in GAG-binding, antiviral activity, and intracellular Ca2+ signaling and support a model in which GAGs play a key role in the biological activities of this chemokine. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens