Protein Name C-C motif chemokine ligand 5
Organism Homo sapiens
Gene ID 6352
Gene Symbol


UniProt P13501 (CCL5_HUMAN), D0EI67 (D0EI67_HUMAN), A0A494C1Q1 (A0A494C1Q1_HUMAN)
Relationships Total Number of functionally related compound(s) : 751
Total Number of Articles : 1020

C-C motif chemokine ligand 5

Gene Summary

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

  • C-C motif chemokine 5
  • T-cell specific protein p288
  • beta-chemokine RANTES
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