CPRiL

CCL5

C-C motif chemokine ligand 5

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

• C-C motif chemokine 5
• T-cell specific protein p288
• beta-chemokine RANTES
chemokine (C-C motif) ligand 5
eosinophil chemotactic cytokine
regulated upon activation, normally T-expressed, and presumably secreted
small inducible cytokine subfamily A (Cys-Cys), member 5
D17S136E
RANTES
SCYA5
SIS-delta
SISd
TCP228
eoCP