Title : Differential time courses of exogenous 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine and its metabolite MPP+ in the rat striatum and nucleus accumbens measured using in vivo voltammetry.

Pub. Date : 1998 Nov 23

PMID : 9813295






1 Functional Relationships(s)
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1 These results indicate that the difference in the pharmacokinetics of exogenously applied MPTP in the striatum and nucleus accumbens may be due to a difference in uptake in these regions, and that the difference in pharmacokinetics of endogenously produced MPP+ may be due to differences in both uptake and monoamine oxidase-B activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Rattus norvegicus