Title : Relationship between in vivo FK506 clearance and in vitro 13-demethylation activity in living-related liver transplantation.

Pub. Date : 1998 Oct 27

PMID : 9808496






1 Functional Relationships(s)
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1 BACKGROUND: Although it is important to maintain an appropriate blood concentration of FK506 after liver transplantation, significant interindividual variability in the actual FK506 dosage has been observed, presumably due to the wide variability of cytochrome P450 3A4 activity in liver microsomes. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens