Pub. Date : 1998 Nov 1
PMID : 9794429
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition by dexamethasone of antigen-induced c-Jun N-terminal kinase activation in rat basophilic leukemia cells. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Pretreatment with dexamethasone (10 and 100 nM) for 18 h inhibited the Ag-induced increase in JNK activity in a concentration-dependent manner. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | At least 6 h of preincubation with dexamethasone was necessary to inhibit the Ag-induced JNK activation. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | The Ag-induced activation of the JNK kinase kinase mitogen-activated protein kinase-extracellular signal-regulated kinase kinase-1 was also inhibited by pretreatment with dexamethasone at 10 and 100 nM. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 5 | These findings indicate that dexamethasone reduces JNK protein level and inhibits the Ag-induced activation of JNK resulting in the inhibition of c-Jun phosphorylation. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 6 | These findings indicate that dexamethasone reduces JNK protein level and inhibits the Ag-induced activation of JNK resulting in the inhibition of c-Jun phosphorylation. | Dexamethasone | mitogen-activated protein kinase 8 | Rattus norvegicus |