Title : Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.

Pub. Date : 1998 Sep 24

PMID : 9794236






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Csk phosphorylates Src family protein tyrosine kinases on a tyrosine residue near their C-terminus and downregulates their activity. Tyrosine C-terminal Src kinase Homo sapiens
2 Mutation of the tyrosine autophosphorylation site of Yes to a phenylalanine resulted in a mutant Yes enzyme that can be fully inactivated by a sub-stoichiometric amount of Csk in a time-dependent manner. Tyrosine C-terminal Src kinase Homo sapiens