Pub. Date : 1998 Oct
PMID : 9792140
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |
| 2 | We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fluorouracil (5-FU)-induced apoptosis of human colon cancer cell lines. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |
| 3 | We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fluorouracil (5-FU)-induced apoptosis of human colon cancer cell lines. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |
| 4 | In cells containing wild-type p53 (e.g. LoVo), 5-FU-induced apoptosis was accompanied by increased expression of Bax and Bak without consistent modulation of other bcl-2 family proteins. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |
| 5 | In conclusion, these results suggest that some members of the Bcl-2 family of proteins, in human colon cancer cell lines, are modulated by 5-FU and that the ratio of Bcl-X(L) to Bax may be related to chemosensitivity to 5-FU. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |
| 6 | In conclusion, these results suggest that some members of the Bcl-2 family of proteins, in human colon cancer cell lines, are modulated by 5-FU and that the ratio of Bcl-X(L) to Bax may be related to chemosensitivity to 5-FU. | Fluorouracil | BCL2 apoptosis regulator | Homo sapiens |