Title : Effect of FK506 on the activation state of hepatic macrophages in Propionibacterium acnes-treated rats.

Pub. Date : 1998 Sep

PMID : 9792034






2 Functional Relationships(s)
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1 FK506 administration attenuated hepatic-mRNA expression of interleukin-2 and both superoxide anions as well as tumour necrosis factor-alpha production by hepatic macrophages, but did not change CD14-mRNA expression in Propionibacterium acnes-treated rats. Tacrolimus interleukin 2 Rattus norvegicus
2 FK506 seems to attenuate such activation by suppressing hepatic interleukin-2 expression, without affecting CD14 expression on the cells. Tacrolimus interleukin 2 Rattus norvegicus