Title : Drug binding and nucleotide hydrolyzability are essential requirements in the vanadate-induced inhibition of the human P-glycoprotein ATPase.

Pub. Date : 1998 Oct 20

PMID : 9778376






2 Functional Relationships(s)
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1 Preincubation of human Pgp expressed in Sf9 insect cells with vanadate in the presence of Mg2+, ATP, and verapamil resulted in nearly complete and stable inhibition of the drug-stimulated ATPase function. magnesium ion ATP binding cassette subfamily B member 1 Homo sapiens
2 In support of this conclusion, vanadate, in the presence of Mg2+ and verapamil, caused selective trapping of 8-azido [alpha-32P] ATP and covalent labeling of ATP-binding site in the Pgp. magnesium ion ATP binding cassette subfamily B member 1 Homo sapiens