Title : Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.

Pub. Date : 1998 Oct 1

PMID : 9766669






2 Functional Relationships(s)
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1 Strong CPA chemosensitivity was also seen following transduction of CYP2C18-Met, despite a very low level of CYP protein expression (>60-fold lower than that of 2B6). Cyclophosphamide cytochrome P450 family 2 subfamily C member 18 Homo sapiens
2 CYP2B6 plus P450 reductase and CYP2C18-Met plus P450 reductase thus appear to be excellent gene combinations for use with CPA in P450/prodrug activation-based cancer gene therapy. Cyclophosphamide cytochrome P450 family 2 subfamily C member 18 Homo sapiens