Title : Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines.

Pub. Date : 1998 Oct

PMID : 9756612






3 Functional Relationships(s)
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1 However, the dose of poly I:poly C required for efficient IFN induction is so high as occasionally to be cytotoxic. Poly C interferon alpha 1 Homo sapiens
2 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C interferon alpha 1 Homo sapiens
3 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C interferon alpha 1 Homo sapiens