Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.

Pub. Date : 1998 Oct 1

PMID : 9742217






1 Functional Relationships(s)
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1 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. Physostigmine acetylcholinesterase (Cartwright blood group) Homo sapiens