Pub. Date : 1998 Sep 15
PMID : 9739042
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test the hypothesis that PPARalpha is activated as a component of the cellular lipid homeostatic response, the expression of PPARalpha target genes was characterized in response to a perturbation in cellular lipid oxidative flux caused by pharmacologic inhibition of mitochondrial fatty acid import. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | To test the hypothesis that PPARalpha is activated as a component of the cellular lipid homeostatic response, the expression of PPARalpha target genes was characterized in response to a perturbation in cellular lipid oxidative flux caused by pharmacologic inhibition of mitochondrial fatty acid import. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Inhibition of fatty acid oxidative flux caused a feedback induction of PPARalpha target genes encoding fatty acid oxidation enzymes in liver and heart. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Inhibition of fatty acid oxidative flux caused a feedback induction of PPARalpha target genes encoding fatty acid oxidation enzymes in liver and heart. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | In mice lacking PPARalpha (PPARalpha-/-), inhibition of cellular fatty acid flux caused massive hepatic and cardiac lipid accumulation, hypoglycemia, and death in 100% of male, but only 25% of female PPARalpha-/- mice. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 6 | In mice lacking PPARalpha (PPARalpha-/-), inhibition of cellular fatty acid flux caused massive hepatic and cardiac lipid accumulation, hypoglycemia, and death in 100% of male, but only 25% of female PPARalpha-/- mice. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |
| 7 | In mice lacking PPARalpha (PPARalpha-/-), inhibition of cellular fatty acid flux caused massive hepatic and cardiac lipid accumulation, hypoglycemia, and death in 100% of male, but only 25% of female PPARalpha-/- mice. | Fatty Acids | peroxisome proliferator activated receptor alpha | Mus musculus |