Title : Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis.

Pub. Date : 1998 Sep 25

PMID : 9737965






1 Functional Relationships(s)
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1 PHS-1 was incubated with teratogen (phenytoin, mephenytoin, trimethadione, phenobarbital, and major metabolites) or its vehicle and the free radical spin trap alpha-phenyl-N-t-butylnitrone, and incubations were analyzed by EPR spectrometry. Mephenytoin prostaglandin-endoperoxide synthase 1 Homo sapiens