Protein Name prostaglandin-endoperoxide synthase 1
Organism Homo sapiens
Gene ID 5742
Gene Symbol


UniProt P23219 (PGH1_HUMAN), A0A087X296 (A0A087X296_HUMAN)
Relationships Total Number of functionally related compound(s) : 531
Total Number of Articles : 869

prostaglandin-endoperoxide synthase 1

Gene Summary

This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021]

  • prostaglandin G/H synthase 1
  • PGH synthase 1
  • cyclooxygenase-1
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