Pub. Date : 1998 Jul 31
PMID : 9726626
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A 75% inhibition of cholinesterase activity was found 18 h after the last metrifonate administration, while only a 15% inhibition was detectable 18 h after the last tacrine administration. | Trichlorfon | butyrylcholinesterase | Rattus norvegicus |
| 2 | The challenge with metrifonate or tacrine resulted in 90 and 80% cholinesterase inhibition, respectively. | Trichlorfon | butyrylcholinesterase | Rattus norvegicus |
| 3 | These results demonstrate that in aging rats a subchronic treatment with metrifonate results in a long-lasting, cholinesterase inhibition, and a persistent increase in acetylcholine extracellular levels which compensate for the age-associated cholinergic hypofunction. | Trichlorfon | butyrylcholinesterase | Rattus norvegicus |