Title : HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit.

Pub. Date : 1998 Jul

PMID : 9699888






5 Functional Relationships(s)
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1 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus
2 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus
3 Liver HMG-CoA reductase mRNA levels were reduced 73% by cholesterol feeding and drug treatment did not prevent the reduction; however, atorvastatin alone and upon coadministration blunted the decrease in LDL receptor mRNA levels. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus
4 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus
5 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus