PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9699888-0 1998 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 74-85 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus 0-17 9699888-0 1998 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 138-149 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus 0-17 9699888-4 1998 Liver HMG-CoA reductase mRNA levels were reduced 73% by cholesterol feeding and drug treatment did not prevent the reduction; however, atorvastatin alone and upon coadministration blunted the decrease in LDL receptor mRNA levels. Cholesterol 56-67 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus 6-23 9699888-9 1998 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 117-128 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus 31-48 9699888-9 1998 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 199-210 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oryctolagus cuniculus 31-48