Title : Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose- and time-dependent effects of nicotine treatment.

Pub. Date : 1998 Aug

PMID : 9694939






10 Functional Relationships(s)
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1 nAChRs also are targets of nicotine, which acts acutely like acetylcholine to stimulate nAChR function. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 Chronic nicotine treatment induces increases in numbers of human muscle-type nAChRs containing alpha-1, beta-1, gamma and delta subunits, a human ganglionic nAChR subtype containing alpha-3 and beta-4 subunits and a human ganglionic nAChR containing alpha-7 subunits in intracellular and (except for alpha-7 nAChRs) in cell surface pools. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
3 Chronic nicotine treatment induces increases in numbers of human muscle-type nAChRs containing alpha-1, beta-1, gamma and delta subunits, a human ganglionic nAChR subtype containing alpha-3 and beta-4 subunits and a human ganglionic nAChR containing alpha-7 subunits in intracellular and (except for alpha-7 nAChRs) in cell surface pools. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
4 However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
5 However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
6 However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
7 However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
8 Nicotine exposure more potently, more rapidly, and with nAChR-subtype specificity, induces two phases of losses in functional responsiveness of muscle-type nAChRs and alpha-3 beta-4 nAChRs, including a "persistent inactivation" that is distinct from classicly defined "desensitization." Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
9 Based on these results, we hypothesize that chronic nicotine treatment induces persistent functional inactivation and numerical up-regulation of all nAChR subtypes via distinct post-transcriptional mechanisms and with potencies, at rates and with magnitudes that are nAChR-subtype specific. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
10 Based on these results, we hypothesize that chronic nicotine treatment induces persistent functional inactivation and numerical up-regulation of all nAChR subtypes via distinct post-transcriptional mechanisms and with potencies, at rates and with magnitudes that are nAChR-subtype specific. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens