Pub. Date : 1998 Aug
PMID : 9694939
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | nAChRs also are targets of nicotine, which acts acutely like acetylcholine to stimulate nAChR function. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
2 | Chronic nicotine treatment induces increases in numbers of human muscle-type nAChRs containing alpha-1, beta-1, gamma and delta subunits, a human ganglionic nAChR subtype containing alpha-3 and beta-4 subunits and a human ganglionic nAChR containing alpha-7 subunits in intracellular and (except for alpha-7 nAChRs) in cell surface pools. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
3 | Chronic nicotine treatment induces increases in numbers of human muscle-type nAChRs containing alpha-1, beta-1, gamma and delta subunits, a human ganglionic nAChR subtype containing alpha-3 and beta-4 subunits and a human ganglionic nAChR containing alpha-7 subunits in intracellular and (except for alpha-7 nAChRs) in cell surface pools. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
4 | However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
5 | However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
6 | However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
7 | However, the half-maximal potency with which nicotine has these effects differs across these nAChR subtypes, as do rates and magnitudes of the "nicotine-induced nAChR up-regulation." | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
8 | Nicotine exposure more potently, more rapidly, and with nAChR-subtype specificity, induces two phases of losses in functional responsiveness of muscle-type nAChRs and alpha-3 beta-4 nAChRs, including a "persistent inactivation" that is distinct from classicly defined "desensitization." | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
9 | Based on these results, we hypothesize that chronic nicotine treatment induces persistent functional inactivation and numerical up-regulation of all nAChR subtypes via distinct post-transcriptional mechanisms and with potencies, at rates and with magnitudes that are nAChR-subtype specific. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
10 | Based on these results, we hypothesize that chronic nicotine treatment induces persistent functional inactivation and numerical up-regulation of all nAChR subtypes via distinct post-transcriptional mechanisms and with potencies, at rates and with magnitudes that are nAChR-subtype specific. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |