Title : Blockade of HERG and Kv1.5 by ketoconazole.

Pub. Date : 1998 Aug

PMID : 9694927






1 Functional Relationships(s)
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1 These potential dual actions on HERG currents suggest that precautions should be taken in long-term ketoconazole treatment, particularly for patients who have decreased liver function or are on a drug regimen requiring simultaneous medications that use cytochrome-P450 for breakdown, such as terfenadine or erythromycin, or Class III antiarrhythmic drugs. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens