Title : Receptor-mediated effects of endothelin on the L-type Ca++ current in ventricular cardiomyocytes.

Pub. Date : 1998 Aug

PMID : 9694918






2 Functional Relationships(s)
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1 The purpose of this study was to establish whether specific receptor subtypes are responsible for mediating the effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on the L-type calcium current (ICa) using a number of receptor-selective antagonists, including PD155080 (ETA), BQ-788, RES-701 and IRL-1038 (ETB) and the ETA/ETB receptor-non-selective antagonist PD145065. Calcium endothelin-1 Oryctolagus cuniculus
2 The purpose of this study was to establish whether specific receptor subtypes are responsible for mediating the effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on the L-type calcium current (ICa) using a number of receptor-selective antagonists, including PD155080 (ETA), BQ-788, RES-701 and IRL-1038 (ETB) and the ETA/ETB receptor-non-selective antagonist PD145065. Calcium endothelin-1 Oryctolagus cuniculus