Pub. Date : 1998 Jul 27
PMID : 9686762
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since L-ornithine is metabolized to growth-stimulatory polyamines, we examined whether thrombin regulates the transcellular transport and metabolism of L-ornithine by vascular SMCs. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 2 | Treatment of SMCs with thrombin initially (0 to 2 hours) decreased L-ornithine uptake, whereas longer exposures (6 to 24 hours) progressively increased transport. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 3 | Kinetic studies indicated that thrombin-induced inhibition was associated with a decrease in affinity for L-ornithine, whereas stimulation was mediated by an increase in transport capacity. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 4 | Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 5 | The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 6 | The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 7 | The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 8 | Thrombin also markedly increased the capacity of SMCs to generate putrescine, a polyamine, from extracellular L-ornithine. | Ornithine | coagulation factor II, thrombin | Homo sapiens |
| 9 | The ability of thrombin to upregulate L-ornithine transport and direct its metabolism to growth-stimulatory polyamines may contribute to postangioplasty restenosis and atherosclerotic lesion formation. | Ornithine | coagulation factor II, thrombin | Homo sapiens |