Title : Glucocorticoids inhibit CD40 ligand expression of peripheral CD4+ lymphocytes.

Pub. Date : 1998 Jul 10

PMID : 9682002






4 Functional Relationships(s)
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1 We show that dexamethasone in vitro inhibits CD40L expression in a dose-dependent manner in concentrations ranging from 0.1 to 1 mg/mL. Dexamethasone CD40 ligand Homo sapiens
2 The inhibitory effect of dexamethasone on CD40L expression was reversible and not due to affection of cell viability. Dexamethasone CD40 ligand Homo sapiens
3 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Dexamethasone CD40 ligand Homo sapiens
4 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Dexamethasone CD40 ligand Homo sapiens