| Protein Name | signal transducer and activator of transcription 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6773 |
| Gene Symbol | STAT2 |
| UniProt | P52630 (STAT2_HUMAN), R9QE65 (R9QE65_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
88
Total Number of Articles : 122 |
Description |
signal transducer and activator of transcription 2 |
| Gene Summary |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020] |
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