Title : Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML.

Pub. Date : 1998 Aug

PMID : 9671498






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutant PML proteins containing either a Cys point mutation within the N-terminal RING finger domain or a small deletion (of positions 281 to 304) within the coiled-coil region did not localize to the PODs but instead gave a nuclear diffuse distribution, similar to that produced by intact PML in the presence of IE1. Cysteine PML nuclear body scaffold Homo sapiens