Title : Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.

Pub. Date : 1998 Jul 9

PMID : 9671310






1 Functional Relationships(s)
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1 Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors. sodium arsenite HRas proto-oncogene, GTPase Homo sapiens