Title : Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

Pub. Date : 1998 Jul 24

PMID : 9668078






2 Functional Relationships(s)
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1 The number of mitotic cells was highest at 24 h (82%), then declined as arrested cells progressed into apoptosis, and barely no mitotic cells were present at 48-60 h. The time curves of paclitaxel-induced cyclin B1 accumulation and stimulation of Cdc2/cyclin B1 kinase activity were identical and superimposable to that of M phase arrest. Paclitaxel cyclin dependent kinase 1 Homo sapiens
2 Immune complex kinase assays in cell-free systems demonstrated that Bcl-2 protein can be a substrate of Cdc2/cyclin B1 kinase isolated from paclitaxel-treated cells arrested in M phase. Paclitaxel cyclin dependent kinase 1 Homo sapiens