Title : EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

Pub. Date : 1998 Aug

PMID : 9664130






1 Functional Relationships(s)
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1 We found that both the anti-EGFR mAbs and the TK inhibitor produce similar biological changes namely, they inhibit the EGF and TGFa-induced tyrosine phosphorylation of the receptor and the growth in culture of HN5 cells. Tyrosine transforming growth factor alpha Homo sapiens