Title : The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.

Pub. Date : 1998 Jul

PMID : 9655895






2 Functional Relationships(s)
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1 Accompanying behavioral sensitization were two postsynaptic neuroadaptive responses: reduction in the ability of Amp to induce c-fos gene expression in the infralimbic/ventral prelimbic cortex and NT/N mRNA in the accumbal shell. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 However, concurrent blockade of D4 receptors during Amp pretreatment prevented the refractoriness in c-fos and NT/N responsiveness to acute Amp. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus