Pub. Date : 1998 Jul
PMID : 9651189
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells. | monocrotaline pyrrole | cyclin dependent kinase 1 | Bos taurus |
| 2 | Western blot examination revealed that by 24 h of MCTP exposure, the phosphorylation state of cdc2 was consistent with the inactive form of the kinase (confirmed by biochemical assay); this alteration persisted through at least 96 h of exposure. | monocrotaline pyrrole | cyclin dependent kinase 1 | Bos taurus |
| 3 | We conclude that MCTP induces a progressive irreversible endothelial cell dysfunction leading to inactivation of cdc2 kinase and irreversible cell-cycle arrest at the G2 checkpoint. | monocrotaline pyrrole | cyclin dependent kinase 1 | Bos taurus |