Title : V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation.

Pub. Date : 1998 Jul 1

PMID : 9647226






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 One such substrate, phospholipase C (PLC)-gamma1, becomes tyrosine phosphorylated on CD3/TCR activation and mediates inositol triphosphate-dependent Ca2+ flux. Tyrosine phospholipase C gamma 1 Homo sapiens
2 Co-cross-linking of T cells with anti-CD3 and anti-V7 resulted in selective inhibition of PLC-gamma1 tyrosine phosphorylation, which may explain V7-mediated blockade of anti-CD3-induced Ca2+ flux. Tyrosine phospholipase C gamma 1 Homo sapiens