Title : Atrial natriuretic factor-induced amylase output in the rat parotid gland appears to be mediated by the inositol phosphate pathway.

Pub. Date : 1998 Jun 9

PMID : 9636666






6 Functional Relationships(s)
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1 In previous in vivo studies we have reported that atrial natriuretic factor enhanced induced salivary secretion and increased isoproterenol-induced amylase release in the rat suggesting that, ANF effect could be mediated by phosphatidylinositol hydrolysis. Isoproterenol natriuretic peptide A Rattus norvegicus
2 In previous in vivo studies we have reported that atrial natriuretic factor enhanced induced salivary secretion and increased isoproterenol-induced amylase release in the rat suggesting that, ANF effect could be mediated by phosphatidylinositol hydrolysis. Isoproterenol natriuretic peptide A Rattus norvegicus
3 Furthermore 100 nM ANF enhanced isoproterenol-evoked amylase release. Isoproterenol natriuretic peptide A Rattus norvegicus
4 This effect was abolished in the presence of neomycin supporting ANF direct stimulation of phospholipase C. These results suggest the involvement of the C type natriuretic peptide receptor coupled to phospholipase C in ANF evoked amylase release and ANF enhancement of the isoproterenol-induced output of the enzyme. Isoproterenol natriuretic peptide A Rattus norvegicus
5 This effect was abolished in the presence of neomycin supporting ANF direct stimulation of phospholipase C. These results suggest the involvement of the C type natriuretic peptide receptor coupled to phospholipase C in ANF evoked amylase release and ANF enhancement of the isoproterenol-induced output of the enzyme. Isoproterenol natriuretic peptide A Rattus norvegicus
6 This effect was abolished in the presence of neomycin supporting ANF direct stimulation of phospholipase C. These results suggest the involvement of the C type natriuretic peptide receptor coupled to phospholipase C in ANF evoked amylase release and ANF enhancement of the isoproterenol-induced output of the enzyme. Isoproterenol natriuretic peptide A Rattus norvegicus