Title : Synthesis of cobalamin coenzymes by human lymphocytes in vitro and the effect of folates and metabolic inhibitors.

Pub. Date : 1976 Oct

PMID : 963297






2 Functional Relationships(s)
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1 Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it. Folic Acid Cbl proto-oncogene Homo sapiens
2 This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis. Folic Acid Cbl proto-oncogene Homo sapiens